Composition comprising hydrophilized sulfasalazine and hyaluronic acid for the treatment of osteoarthritis and method for producing the same

摘要

The present invention relates to a composition for the treatment of osteoarthritis and a method for producing the same, and more particularly to preventing joint wear as well as pain relief through joint cavity injection and local administration, and effective for osteoarthritis such as degenerative osteoarthritis. The present invention relates to a composition containing sulfasalazine hydrophilized as an active ingredient and additionally hyaluronic acid so that it can be easily treated, and a method for producing the same. When such a composition for osteoarthritis treatment is produced by the production method according to the present invention, the dissolved state is maintained even after a neutralization step after dissolution, and precipitation due to salting-out phenomenon of sulfasalazine generated after neutralization is prevented. From the above, a composition containing sulfasalazine at a high concentration can be produced, and the composition produced thereby contains sulfasalazine, which has been conventionally contained only at a low concentration due to poor solubility, thereby allowing joint cavity injection and It is very useful for the treatment of osteoarthritis through local administration, especially degenerative osteoarthritis. [Selection] Figure 5