Selective inhibitors of clinically important variants of EGFR tyrosine kinase

摘要

The present invention relates to compounds of the formula (I) or a subgeneric structure or species thereof, or pharmaceutically acceptable salts, esters, solvates and / or prodrugs thereof and abnormal cell growth such as cancer Provide methods and compositions for treating or ameliorating sexual disorders, wherein A, R ² , R ³ , R ¹⁰ , E ¹ , E ² , E ³ , Y, and Z are defined herein As it is. The compounds and salts of the invention inhibit kinases, in particular epidermal growth factor receptor EGFR, and certain variants thereof that are important in developing resistance to treatment with EGFR inhibition therapy, such as cancer, etc. Useful for treating or ameliorating aberrant cell proliferative disorders. 【Selection chart】 None