6,7,8,9-tetrahydro-5H-pyrido 2,3-d azepine dopamine D3 ligand

摘要

The present invention relates to a compound of formula (I) and pharmaceutically acceptable salts thereof, wherein the variables R ¹ , R ² , R ³ , R ⁴ , R ⁵ , a and A are defined herein. Processes for preparing such compounds and salts; intermediates used in their preparation; and compositions containing them, and eg substance addiction, substance abuse, schizophrenia (eg Cognitive symptoms), cognitive impairment (eg, schizophrenia, cognitive impairment associated with AD or PD), D3 mediated (or D3-related) including Parkinson''s disease, mania, anxiety, impulse control disorders, sexual disorders and depression Provide their use to treat disorders. [Chemical 1]