Voriconazole intermediate and method for synthesizing voriconazole

摘要

The present invention provides a novel method for synthesizing a voriconazole intermediate condensate represented by Formula II or an acid addition salt thereof, wherein the voriconazole intermediate condensate is represented by Compound Formula III and Formula IV as shown in Reaction Scheme 1. It is obtained by preparing. In the synthesis method provided in the present invention, by adjusting the preparation form, the reaction conditions can be made mild and controllable, the generation of impurities A can be reduced, and the use of lead poison metal is avoided, and Can eliminate the risk of residual chemicals. This makes the product more pure and has great industrial application value. [Reaction Formula 1] [Chemical 1]