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Zwitterionic compound, biocompatible materials are made and its manufacturing method

机译:两性离子化合物,生物相容性材料的制备及其制造方法

摘要

PROBLEM TO BE SOLVED: To provide: a novel amphoteric ion-containing compound used for medical devices, healthcare devices, and the like; a biocompatible material having excellent protein adsorption inhibiting ability; and a method for safely and simply producing the compound.SOLUTION: An amphoteric ion-containing compound (A) having a tertiary amino group and a carboxyl group is obtained by Michael addition of a secondary amino group of a compound (C) having a secondary amino group and a carboxylic group to an ethylenic unsaturated group of a curable compound (B) having two or more ethylenic unsaturated groups. Specifically, provided is the amphoteric ion-containing compound (A) in which the compound (C) having a secondary amino group and a carboxyl group is pyrrolidine-2-carboxylic acid.SELECTED DRAWING: None
机译:要解决的问题:提供:用于医疗设备,医疗保健设备等的新型含两性离子的化合物;具有优异的蛋白质吸附抑制能力的生物相容性材料;解决方案:通过将具有仲氨基的化合物(C)的仲氨基迈克尔加成,获得具有叔氨基和羧基的含两性离子的化合物(A)。具有两个或更多个烯键式不饱和基团的可固化化合物(B)的氨基和羧基至烯键式不饱和基团。具体而言,提供其中具有仲氨基和羧基的化合物(C)为吡咯烷-2-羧酸的含两性离子的化合物(A)。

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