Sterile aqueous formulations for injection based on crosslinked hyaluronic acid and hydroxyapatite for therapeutic use

摘要

This invention relates to an absorbable sterile injectable aqueous formulation that is ready to use, used for therapeutic purposes as a cohesive particle-based viscoelastic gel containing i) cross-linked hyaluronic acid, or one of its salts, at a concentration between 1% and 4% (mass/volume), with the cross-linking that is performed making it possible to obtain a gel having a base of cross-linked hyaluronic acid having a so-called cohesive structure, and ii) hydroxyapatite. at a concentration between 10% and 70% (mass/volume), said hydroxyapatite being in the form of particles having an average size less than or equal to 650 m; with the said sterile injectable aqueous formulation having viscoelastic properties such that Tan at a frequency of 1 Hz is less than or equal to 0.60.