Test method of cognitive dysfunction using acrolein metabolite in urine and creatinine as index

摘要

PROBLEM TO BE SOLVED: To find biomarkers that can be used to determine cases of dementia and mild cognitive impairment, a precursor to dementia, and provide a novel method of testing for these diseases using such biomarkers.SOLUTION: Disclosed are; a method of testing for dementia and/or mild cognitive impairment using, as biomarkers, a ratio (3-HPMA/Cre) of 3-hydroxypropylmercapturic acid (hereunder referred to as 3-HPMA) content to creatinine (hereunder referred to as Cre) content in a urine sample taken from a subject, and/or a ratio (AC-Acro/Cre) of acrolein-conjugated amino acid (hereunder referred to as AC-Acro) content to Cre content in the urine sample; a test method of discriminating mild cognitive impairment from Alzheimer's dementia including the use of the biomarkers; a test kit for dementia and/or mild cognitive impairment including reagents for measuring 3-HPMA content and/or AC-Acro content in a urine sample; and a test kit for discriminating mild cognitive impairment from Alzheimer's dementia including the reagents.SELECTED DRAWING: None