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Human application of modified chimeric antigen receptor (CAR) T cells
Human application of modified chimeric antigen receptor (CAR) T cells
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机译:修饰的嵌合抗原受体(CAR)T细胞在人类中的应用
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摘要
The present invention concerns methods and compositions for immunotherapy employing a modified T cell comprising a chimeric antigen receptor (CAR). In particular aspects, CAR-expressing T-cells are producing using electroporation in conjunction with a transposon-based integration system to produce a population of CAR-expressing cells that require minimal ex vivo expansion or that can be directly administered to patients for disease (e.g., cancer) treatment.
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