Administration of a drug through the blood brain barrier using stimuli-responsive nanoparticles

摘要

A method of administering a drug into the brain of a mammal (human or nonhuman) is described. In this method, a magneto-electric nanoparticle (MENP) and a drug are injected into the blood stream of a mammal. The MENP attaches to the blood-brain barrier (BBB) and a non-alternating electric or magnetic field is applied. In an alternative, the non-alternating field could be replaced by a slowly alternating field so as to avoid localized heating. The step of applying an electric or magnetic field causes an increase in the permeability of the BBB to the drug so that the drug passes into the brain while the MENP remains attached to the BBB.