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Angiogenic conditioning to enhance cardiac cellular reprogramming of fibroblasts of the infarcted myocardium
Angiogenic conditioning to enhance cardiac cellular reprogramming of fibroblasts of the infarcted myocardium
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机译:血管生成调节可增强梗死心肌成纤维细胞的心脏细胞重编程
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摘要
Provided is a method of treating coronary artery disease in a mammal, comprising administering to a region of the heart of the mammal (a) a first vector encoding one or more angiogenic proteins which induce vascularization in the heart of the mammal, and (b) a second vector encoding one or more cardio-differentiating transcription factors which induce the production of induced cardiomyocytes (iCM) in the heart of the mammal, whereby the coronary artery disease in the mammal is treated. In a preferred embodiment, the first vector is an adenoviral vector encoding VEGF and the second vector is a lentiviral vector encoding Gata4, Mef2c, and Tbx5 (GMT).
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