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Selective modulators of the activity of the GPR55 receptor: chromenopyrazole derivatives

机译:GPR55受体活性的选择性调节剂:苯并吡咯衍生物

摘要

The present invention relates to a family of chromenopyrazole derivatives of formula (I):; embedded image which have the ability to modulate the receptor of the cannabinoid family GPR55, whereby the invention also relates to the use of these compounds for the manufacture of a medicament for the treatment of diseases in which the GPR55 receptor has a physiological role such as diabetes, Parkinson's disease, multiple sclerosis, neuropathic pain, osteoporosis and cancers such as cholangiocarcinoma, breast cancer, ovarian and prostate cancer, glioblastoma, and cutaneous carcinoma.
机译:本发明涉及式(I)的苯并吡唑衍生物家族: “嵌入式图像” 它们具有调节大麻素家族GPR55的受体的能力,因此本发明还涉及这些化合物在制备用于治疗其中GPR55受体具有生理作用的疾病例如糖尿病,帕金森氏病的药物中的用途。疾病,多发性硬化症,神经性疼痛,骨质疏松症和癌症,例如胆管癌,乳腺癌,卵巢癌和前列腺癌,胶质母细胞瘤和皮肤癌。

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