The invention is a method for exploitation of a sedimentary basin containing hydrocarbons using basin simulation. Based on a reconstitution of the formation of the first of the layers of the basin, a conjoint basin simulations of at least one of the layers underlying the first layer. A conjoint geomechanical simulation of the first layer and the at least one underlying layer is then carried out. If the deviation between some of at least some parameters from the geomechanical simulation and those from the basin simulation is above a predefined threshold, the previous steps are repeated applying a correction to the basin simulation. The basin is then exploited as a function of the results of the basin simulation. The invention applied to exploration and exploitation of the basin.
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