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INJECTABLE SOLUTION AT PH 7 COMPRISING AT LEAST ONE BASAL INSULIN WHEREIN THE PI IS COMPRISED FORM 5.8 TO 8.5 AND A CO-POLYAMINO ACID BEARING CARBOXYLATE CHARGES AND HYDROPHOBIC RADICALS
INJECTABLE SOLUTION AT PH 7 COMPRISING AT LEAST ONE BASAL INSULIN WHEREIN THE PI IS COMPRISED FORM 5.8 TO 8.5 AND A CO-POLYAMINO ACID BEARING CARBOXYLATE CHARGES AND HYDROPHOBIC RADICALS
In one embodiment, the composition according to the invention is characterized in that the co-polyamino acid bearing carboxylate charges and at least one hydrophobic radical -Hy is chosen among the co-polyamino acids according to formula XXXb hereinafter:; ;wherein,D represents, independently, either a group —CH2— (aspartic acid) or a group —CH2—CH2— (glutamic acid),X represents a cationic entity chosen in the group comprising alkali cations,Rb and Rb′, identical or different, are either a hydrophobic radical -Hy, or a radical chosen in the group consisting of an H, a C2 to C10 linear acyl group, a C3 to C10 branched acyl group, a benzyl, a terminal “amino acid” unit and a pyroglutamate, at least one of Rb and R′b is a hydrophobic radical -Hy,Q and Hy are as defined above.n+m represents the degree of polymerization DP of the co-polyamino acid, namely the mean number of monomeric units per co-polyamino acid chain and 5≤n+m≤250.展开▼
机译：在一个实施方案中，根据本发明的组合物的特征在于，具有羧酸盐电荷和至少一个疏水基团-Hy的共聚氨基酸选自下文根据式XXXb的共聚氨基酸： ;其中 D分别表示基团-CH 2 -（天冬氨酸）或基团-CH 2 -CH 2 -（谷氨酸）， X表示在包含碱金属阳离子的组中选择的阳离子实体， R b 和R b '相同或不同，是疏水性基团-Hy或选自以下的基团H，C2至C10线性酰基，C3至C10支链酰基，苄基，末端“氨基酸”单元和焦谷氨酸， Rb和R'b中的至少一个是疏水基-Hy， Q和Hy如上定义。 n + m表示共聚氨基酸的聚合度DP，即每个共聚氨基酸链的平均单体单元数，且5≤n+m≤250。
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