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SYSTEM AND METHOD FOR ARRESTING DEBILITATING MIGRAINE EVENTS

机译:抢夺使微妙事件发生的系统和方法

摘要

A system and method for treating acute migraine events utilizing multiple sensory/receptive channels (olfactory, audio, visual and other sensory receptors) to both treat and optimize delivery to the afflicted sites in the brain. One of the primary migraine treatment methods includes a composition delivered through the olfactory system. Absorption through the nasal membranes is rapid and avoids delays and dilution inherent in methods using the mouth and gastro-intestinal (GI) processing. Effective, but less preferred methods that avoid GI delays and dilution include delivery as eyedrops or as an intravenous infusion. The effective composition comprises a caffeinic substance to bind and antagonize adenosine receptors in the brain. This immediately blocks continued action of adenosine to dilate the afflicted vessels and inflict pain. The composition also incorporates cannabinolic substances which work simultaneously or in parallel using the body's natural endocannabinoid pathways to rebalance and control blood flow to minimize swelling and pain. Additional features may incorporate additional active components. One available feature may incorporate a recipient/patient control modulus where the patient adjusts treatment using a feedback device such as a stimulation button to increase or adjust delivery. Another additional feature comprises one or more essential oils. Although some essential oil compositions may themselves include one or more compounds that contribute to the desired cannabinolic effects, adding essential oils even those lacking an inherent cannabinolic effect can contribute to effective treatment. Fragrant inclusions in an essential oil additive may provide a calming stimulation to the olfactory system that supports reduced tension and relaxation and thereby removes a tension induced exacerbation of migraine progression.
机译:一种利用多个感觉/接受通道(嗅觉,听觉,视觉和其他感觉受体)治疗急性偏头痛事件的系统和方法,可以治疗并优化向脑部受累部位的输送。一种主要的偏头痛治疗方法包括通过嗅觉系统递送的组合物。通过鼻膜吸收迅速,避免了使用口腔和胃肠(GI)处理方法固有的延迟和稀释。避免胃肠道延迟和稀释的有效方法,但次优选方法包括滴眼液或静脉输注。有效的组合物包含能结合和拮抗大脑中腺苷受体的咖啡因物质。这立即阻止了腺苷继续作用以扩张患处血管并造成疼痛。该组合物还掺入了大麻素,它们可以利用人体的天然内源性大麻素途径同时或并行发挥作用,以重新平衡和控制血流,从而最大程度地减少肿胀和疼痛。其他功能可能包含其他活动组件。一种可用的特征可以包括接收者/患者控制模量,其中患者使用诸如刺激按钮之类的反馈设备来调整治疗以增加或调整输送。另一个附加特征包括一种或多种精油。尽管某些精油组合物本身可能包括一种或多种有助于所需大麻素作用的化合物,但即使没有固有的大麻素作用,添加精油也可有助于有效治疗。香精油添加剂中的芳香夹杂物可以为嗅觉系统提供镇静刺激,从而支持减少的紧张感和放松感,从而消除因紧张引起的偏头痛恶化。

著录项

  • 公开/公告号US2019275270A1

    专利类型

  • 公开/公告日2019-09-12

    原文格式PDF

  • 申请/专利权人 RICHARD POSTREL;

    申请/专利号US201815913983

  • 发明设计人 RICHARD POSTREL;

    申请日2018-03-07

  • 分类号A61M15;A61K9;A61M11/08;A61K31/352;

  • 国家 US

  • 入库时间 2022-08-21 12:14:14

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