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Gene-deleted variant strain of porcine pseudorabies virus, vaccine composition, method of making the same and use thereof
Gene-deleted variant strain of porcine pseudorabies virus, vaccine composition, method of making the same and use thereof
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机译:猪伪狂犬病毒基因缺失的变异株,疫苗组合物,其制备方法及其用途
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摘要
The present invention provides an attenuated strain of porcine pseudorabies virus (PRV), in which said attenuated strain of PRV is a variant strain of PRV with inactivation of gI/gE/11K/28K proteins. In addition, the present invention also provides a vaccine composition comprising the attenuated strain of PRV as an antigen, a preparation method and use thereof. Proved by immunogenicity and pathogenicity testing of the live vaccine, said live PRV vaccine can provide a good protection for pigs with no clinical signs observed, indicating excellent immune protection.
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机译:本发明提供了猪伪狂犬病病毒(PRV)的减毒株,其中所述PRV减毒株是具有gI / gE / 11K / 28K蛋白失活的PRV的变异株。另外,本发明还提供了包含减毒的PRV株作为抗原的疫苗组合物,其制备方法和用途。通过活疫苗的免疫原性和致病性测试证明,活PRV疫苗可以为未观察到临床症状的猪提供良好的保护,表明具有出色的免疫保护作用。
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