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Nucleic acids encoding a fusion protein useful for multi-level specific targeting of cancer cells
Nucleic acids encoding a fusion protein useful for multi-level specific targeting of cancer cells
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机译:编码融合蛋白的核酸可用于癌细胞的多层次特异性靶向
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摘要
A compound comprising, in combination: a cell surface binding ligand or internalizing factor, such as an IL-13Rα2 binding ligand; at least one effector molecule (e.g., one, two, three or more effector molecules); optionally but preferably, a cytosol localization element covalently coupled between said binding ligand and said at least one effector molecule; and a subcellular compartment localization signal element covalently coupled between said binding ligand and said at least one effector molecule (and preferably with said cytosol localization element between said binding ligand and said subcellular compartment localization signal element). Methods of using such compounds and formulations containing the same are also described.
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