Evaluating Electroencephalogram (EEG) data includes receiving initial EEG signals for a patient being subjected to an anesthetic agent to minimize a response to surgical stimulation; based on a similarity between the initial EEC signals and a corpus of historical EEG signals, identifying a reference series of EEG signals, wherein the reference series of EEG signals comprises a time-ordered sequence of expected EEG signals for the patient; receiving a subsequent EEG signal for the patient after a change to a level of the anesthetic agent has occurred; and displaying a difference between the subsequent EEG signal and a one of the expected EEG signals, wherein the difference is indicative of a probability that the patient will respond to surgical stimulation.
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