embedded image ;A method on its extraction: grinding the husk and fruit stem of Xanthoceras sobifolia into particles, extracting the particles with solvents, filtrating, reclaiming the solvent and collecting the concentrated solution, passing the collection through macroporous resin, eluting it by solvent, reclaiming the solvent to get the enriched solution, drying the solution to form a brown solid which called total saponins; then dissolving the total saponins in water, extracting by normal butyl alcohol, having the extraction dried to obtain brown powder, chromatographing the powder resolved solution by silica gel column repeatedly, receipting the gradient elution with 100:(35˜60) chloroform:methanol, reclaiming the eluted solution, refining and re-crystallize the left solution, will obtain the white raphide which is the invention compound—Xanthoceraside. It is verified that the compound can be used to make medicine to treat brain diseases and tumors, and to make health food to prevent and cure brain diseases and tumors."/> Compound extracted from husk and fruit stem of <I>Xanthoceras sobifolia </I>and its extracting method and use thereof
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Compound extracted from husk and fruit stem of Xanthoceras sobifolia and its extracting method and use thereof

机译:茄子异黄果壳和果茎中提取的化合物及其提取方法和用途

摘要

This invention relates to the compound extracted from husk and fruit stem of Xanthoceras sobifolia and its extracting method and use thereof. Its chemical structure is as below:; embedded image ;A method on its extraction: grinding the husk and fruit stem of Xanthoceras sobifolia into particles, extracting the particles with solvents, filtrating, reclaiming the solvent and collecting the concentrated solution, passing the collection through macroporous resin, eluting it by solvent, reclaiming the solvent to get the enriched solution, drying the solution to form a brown solid which called total saponins; then dissolving the total saponins in water, extracting by normal butyl alcohol, having the extraction dried to obtain brown powder, chromatographing the powder resolved solution by silica gel column repeatedly, receipting the gradient elution with 100:(35˜60) chloroform:methanol, reclaiming the eluted solution, refining and re-crystallize the left solution, will obtain the white raphide which is the invention compound—Xanthoceraside. It is verified that the compound can be used to make medicine to treat brain diseases and tumors, and to make health food to prevent and cure brain diseases and tumors.
机译:本发明涉及从茄果黄单胞菌的果壳和果实茎中提取的化合物及其提取方法和用途。其化学结构如下: “嵌入式图像” ;一种提取方法:将 anthoceras sobifolia 的果壳和果实茎研磨成颗粒,用溶剂萃取颗粒,过滤,回收溶剂并收集浓缩溶液,将收集物通过大孔树脂,用溶剂洗脱,回收溶剂得到浓缩液,干燥后形成褐色固体,称为总皂苷。然后将总皂苷溶解于水中,用正丁醇萃取,将萃取液干燥得到褐色粉末,反复用硅胶柱色谱分离该粉末溶解的溶液,用100:(35〜60)氯仿:甲醇进行梯度洗脱,回收洗脱的溶液,精制并重结晶剩余的溶液,将获得作为本发明的化合物-黄腐苷的白色环糊精。证实该化合物可用于制造治疗脑部疾病和肿瘤的药物,以及制成预防和治疗脑部疾病和肿瘤的保健食品。

著录项

  • 公开/公告号US10160780B2

    专利类型

  • 公开/公告日2018-12-25

    原文格式PDF

  • 申请/专利权人 BAIZHEN YANG;SONGJIANG WANG;

    申请/专利号US201514750349

  • 发明设计人 BAIZHEN YANG;SONGJIANG WANG;CONGFU ZHAO;

    申请日2015-06-25

  • 分类号C07H15/24;A61K31/704;A23L33/105;C07J63;

  • 国家 US

  • 入库时间 2022-08-21 12:13:22

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