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IDENTIFICATION OF GRANINS AS THE PATHOGENIC FACTOR OF ALZHEIMER'S DISEASE AND COMPOSITIONS AND METHODS FOR INHIBITING GRANIN AGGREGATION AND TREATING ALZHEIMER'S DISEASE
IDENTIFICATION OF GRANINS AS THE PATHOGENIC FACTOR OF ALZHEIMER'S DISEASE AND COMPOSITIONS AND METHODS FOR INHIBITING GRANIN AGGREGATION AND TREATING ALZHEIMER'S DISEASE
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机译:识别麸质作为老年痴呆症的致病因素以及抑制麸质凝集和治疗老年痴呆症的成分及方法
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摘要
Compositions for inhibiting the aggregation of a granin from a non-toxic low molecular weight form to a toxic high molecular weight aggregated form and/or dissociating a high molecular weight aggregated form to a low molecular weight form are provided. Such a composition typically includes one or more active compounds or agents, which may also be referred to herein as disaggregation compounds. Using the compounds and compositions described herein, methods of i) modulating, inhibiting or preventing the interaction of granins with metal ions, ii) modulating, inhibiting, preventing the aggregation of granins or dissociating aggregated granins, iii) reducing or inhibiting cell toxicity, iv) treating or preventing dementia or Alzheimer's disease, and v) preventing or treating Parkinson's and/or Huntington's diseases are also provided.
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