首页>
外国专利>
Immunohistochemical proximity assay for PD-1 positive cells and PD-ligand positive cells in tumor tissue
Immunohistochemical proximity assay for PD-1 positive cells and PD-ligand positive cells in tumor tissue
展开▼
机译:肿瘤组织中PD-1阳性细胞和PD-配体阳性细胞的免疫组织化学邻近分析
展开▼
页面导航
摘要
著录项
相似文献
摘要
The present disclosure describes an IHC assay for detecting and quantifying spatially proximal pairs of PD-1-expressing cells (PD-1+ cells) and PD-Ligand-expressing cells (PD-L+ cells) in tumor tissue, and the use of the assay to generate proximity biomarkers that are predictive of which cancer patients are most likely to benefit from treatment with a PD-1 antagonist. The disclosure also provides methods for testing tumor samples for the proximity biomarkers, as well as methods for treating subjects with a PD-1 antagonist based on the test results.
展开▼