ANTIBODIES WHICH SPECIFICALLY BIND FIBROBLAST GROWTH FACTOR RECEPTOR 1, USE OF ANTIBODIES FOR TREATMENT OF ONCOLOGICAL DISEASES, AND ANTIBODIES PRODUCTION METHOD

摘要

The group of inventions relates to biotechnology and medicine and concerns antibodies for treating oncological diseases. The antibodies of the invention specifically bind and block fibroblast growth factor receptor 1 (FGFR1) and are characterized by amino acid sequences H-CDR1, H-CDR2, H-CDR3, L-CDR1, L-CDR2 and L-CDR3. A pharmaceutical composition for treating oncological diseases which contains antibodies of the invention, and a method for treating oncological diseases which involves administering a patient with antibodies of the invention are proposed. Also proposed are: a method for producing antibodies; nucleic acids which encode said antibodies; and cell lines for producing said antibodies. The use of the group of inventions makes it possible, with high effectiveness and specificity, to suppress the proliferation of tumor cells and inhibit tumor angiogenesis by means of blocking the FGF/FGFR1 pathological pathway, which in turn makes it possible to effectively treat oncological diseases.