BK channel-modulating peptides and their use

摘要

The present invention concerns peptides and nucleic acids encoding the peptides, and their use for modulating large conductance Ca²⁺ activated K⁺ (BK) channel activity in cells; for treating conditions such as presbycusis (age-related hearing loss), audiogenic seizures, alcohol addiction, cancer, and neurodegenerative disease; and for delivering a cargo moiety to the brain of a subject through the blood-brain barrier.