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HIGH-ACTIVITY LONG-ACTING HYPOGLYCEMIC FUSION PROTEIN AS WELL AS PREPARATION METHOD AND MEDICAL APPLICATION THEREOF
HIGH-ACTIVITY LONG-ACTING HYPOGLYCEMIC FUSION PROTEIN AS WELL AS PREPARATION METHOD AND MEDICAL APPLICATION THEREOF
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机译:高活性长效降血糖融合蛋白及其制备方法和医学应用
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摘要
The disclosure provides a high-activity long-acting hypoglycemic fusion protein, which is formed by connecting, via a linker peptide or directly, a high-activity Exendin-4 mutant with an optimally mutated Fc fragment of a human immunoglobulin IgG1. The optimally mutated Fc fragment of the human immunoglobulin IgG1 comprises an optimally mutated human IgG1 hinge region and human IgG1 constant regions CH2 and CH3.
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