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COMPOUND FOR ENHANCING ACTIVITY OF ANTIBIOTIC COMPOSITIONS AND OVERCOMING DRUG RESISTANCE
COMPOUND FOR ENHANCING ACTIVITY OF ANTIBIOTIC COMPOSITIONS AND OVERCOMING DRUG RESISTANCE
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机译:增强抗菌成分活性和克服药物耐药性的化合物
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摘要
The present invention discloses a compound—‘ethyl gallate’ which can be used as an activity enhancer for enhancing the activity of antibiotic compositions and also overcoming drug resistance in bacteria. The compound was tested against gram negative, pathogenic bacteria viz. Pseudomonas aeruginosa and Klebsiella pneumoniae in combination with tetracycline, ciprofloxacin and chloramphenicol and found to be highly effective. The effect of the compound is due to its inhibitory action on the efflux pump of the bacteria, due to which even lower concentrations of the antibiotic compositions are highly effective in killing the bacteria. The compound thus offers the technical benefits of enhancing effects of antibiotic compositions at lower dosages and helping to overcome drug resistance in bacteria.
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