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Method of detecting platelet activating antibodies that cause heparin-induced thrombocytopenia/thrombosis
Method of detecting platelet activating antibodies that cause heparin-induced thrombocytopenia/thrombosis
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机译:检测引起肝素诱导的血小板减少症/血栓形成的血小板活化抗体的方法
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摘要
The present invention provides a method of detecting platelet activation in a patient, the method comprising the steps of a) obtaining a blood sample from a patient suspected of having heparin-induced thrombocytopenia (HIT); b) incubating an effective amount of platelet factor 4 (PF4) with a sample of platelets to yield a sample of PF4-treated platelets; c) contacting the patient blood sample with the PF4-treated platelets; and d) measuring the extent of platelet activation, wherein an increase in platelet activation compared with results obtained using a normal blood sample is indicative of the patient having HIT.
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