RADIOFLUORINATED CARBOXIMIDAMIDES AS IDO TARGETING PET TRACER FOR CANCER IMAGING

摘要

Radiofluorinated carboximidamides are disclosed as selective IDO enzyme radioligands and generate specific binding in accordance with IDO expression in vitro. MicroPET experiments indicate [¹⁸F]IDO49 specifically accumulate in IDO-expressing tumors which confirmed by Western blot and IHC analysis supported. Using Hela tumor bearing models with IFN-γ treatment confirmed that [¹⁸F]IDO49 accumulation in the IFN-γ treatment tumor mouse. These results can have implications that [¹⁸F]IDO49 has substantial potential as an imaging agent that targets IDO in tumors.