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ANTIBODIES THAT BIND TO HUMAN ANTI-MÜLLERIAN HORMONE (AMH) AND THEIR USES
ANTIBODIES THAT BIND TO HUMAN ANTI-MÜLLERIAN HORMONE (AMH) AND THEIR USES
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机译:绑定到人类抗穆勒激素(AMH)的抗体及其用途
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摘要
The present invention relates to antibodies or fragments thereof that bind to human Anti-Müllerian hormone (AMH) comprising a heavy chain CDR1 comprising the amino acid sequence of SEQ ID NO: 1, and/or a heavy chain CDR2 comprising the amino acid sequence of SEQ ID NO: 2, and/or a heavy chain CDR3 comprising the amino acid sequence of SEQ ID NO: 3; and/or comprising a light chain CDR1 comprising the amino acid sequence of SEQ ID NO: 4, and/or a light chain CDR2 comprising the amino acid sequence of SEQ ID NO: 5 and/or a light chain CDR3 comprising the amino acid sequence of SEQ ID NO: 6. The present invention further relates to antibodys or fragments thereof that bind to human Anti-Müllerian hormone (AMH) for use in a method for treating cancer in a subject.
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机译:本发明涉及与人抗苗勒氏激素(AMH)结合的抗体或其片段,所述人抗苗勒氏激素包含重链CDR1和重链CDR2,重链CDR1包含SEQ ID NO:1的氨基酸序列,重链CDR2包含SEQ ID NO:1的氨基酸序列。 SEQ ID NO:2,和/或包含SEQ ID NO:3氨基酸序列的重链CDR3;和/或包含包含SEQ ID NO:4的氨基酸序列的轻链CDR1和/或包含SEQ ID NO:5的氨基酸序列的轻链CDR2和/或包含氨基酸序列的轻链CDR3 SEQ ID NO:6的抗体。本发明进一步涉及与人抗苗勒氏管激素(AMH)结合的抗体或其片段,用于治疗受试者的癌症的方法。
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