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FIBROBLAST GROWTH FACTOR (FGF) 1 PROTEINS WITH GLUCOSE LOWERING ABILITY AND REDUCED MITOGENICITY
FIBROBLAST GROWTH FACTOR (FGF) 1 PROTEINS WITH GLUCOSE LOWERING ABILITY AND REDUCED MITOGENICITY
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机译:成纤维细胞生长因子(FGF)1蛋白具有葡萄糖变质能力和降低的致突变性
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摘要
The present disclosure provides FGF1 mutant proteins, which include an N-terminal deletion, point mutation(s), or combinations thereof. In some examples, the mutant FGF1 proteins have reduced mitogenic activity. Also provided are nucleic acid molecules that encode such proteins, and vectors and cells that include such nucleic acids. The disclosed FGF1 mutants can reduce blood glucose in a mammal, and in some examples are used to treat a metabolic disorder.
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