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STRINGS OF EPITOPES USEFUL IN DIAGNOSING AND ELICITING IMMUNE RESPONSES TO SEXUALLY TRANSMITTED INFECTIONS
STRINGS OF EPITOPES USEFUL IN DIAGNOSING AND ELICITING IMMUNE RESPONSES TO SEXUALLY TRANSMITTED INFECTIONS
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机译:在诊断和激发对性传播感染的免疫反应中有用的表位
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摘要
Methods and compositions for detecting and diagnosing sexually transmitted infections using a string of epitopes (SOE) specific for detection of causative microorganisms are provided. The antigenic epitopes may be single epitope sequences, a plurality of epitope sequences joined by amino acid linkers to form a series of epitopes (SOE), or nucleotide sequences encoding one or more SOEs and host cells harboring said SOE nucleotide sequences. SOEs specific for highly immunogenic regions of proteins from Trichomonas, Treponema and Neisseria species are provided. SOEs to detect the presence of trichomonas species comprise regions from Trichomonas aldolase, GAPDH, α-enolase and 60 -actinin proteins. Pharmaceutical compositions comprising SOEs can also be used as vaccines or to elicit an immune response to specific microorganisms.
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