COMPOSITION FOR PREVENTION OR TREATMENT OF METABOLIC SYNDROME OR FOR ANTIOXIDATION CONTAINING BLACK BEAN LEAF EXTRACTS AND FLAVONOL GLYSOSIDES ISOLATED THEREFROM AS ACTIVE INGREDIENTS

摘要

The present invention relates to a composition for prevention or treatment of metabolic syndrome or for antioxidation comprising black soybean leaf extracts and flavonol glycoside compounds isolated thereof as active ingredients. It has been confirmed that the black soybean leaf extracts and the flavonol glycoside compounds isolated thereof in the present invention: effectively inhibit α-glucosidase activity; effectively inhibit LDL oxidation and DDP-4; have excellent DPPH radical scavenging activity; have excellent inhibitory activity of reactive oxygen species (ROS) accumulation; effectively promote insulin secretion in pancreatic beta cells; regulate the expression of major genes for diabetes, obesity, insulin resistance, fatty liver, hyperlipidemia, and atherosclerosis caused by a high-fat diet; have an excellent ability to reduce a waist/hip circumference ratio in adult males and females who are overweight or obese; decrease the concentrations of plasma free fatty acid and plasma triglyceride; increase the concentration of plasma HDL-cholesterol; decrease an atherogenic index; increase erythrocyte catalase, SOD and GR activities; decrease erythrocyte lipid peroxide TBARS; decrease the concentrations of inflammatory cytokines MCP-1 and PAI-1, and resistin which is a hormone secreted in adipocytes; and increase the concentration of plasma adiponectin. Thus, the black soybean leaf extracts and the flavonol glycoside compounds isolated thereof can be usefully used for preventing or treating metabolic syndrome, and also can be usefully used as an antioxidant composition due to the excellent antioxidant activity thereof.