首页>
外国专利>
Integrated Nano System for Liver-Targeting Co-Delivery of Genes/Drugs and Preparation Method
Integrated Nano System for Liver-Targeting Co-Delivery of Genes/Drugs and Preparation Method
展开▼
机译:基因/药物肝靶向共递送的集成纳米系统及其制备方法
展开▼
页面导航
摘要
著录项
相似文献
摘要
The present disclosure discloses an integrated nano system for liver-targeting co-delivery of genes/drugs and a preparation method, belonging to the field of biomedicines. In the disclosure, a plurality of functions are integrated in a carrier having good biocompatibility and safety, a nucleic acid/drug-loading copolymer portion having a pH-stimulating response function is formed by poly(N,N-dimethylaminoethyl methacrylate) (PDMAEMA) grafted with poly(3-azido-2-hydroxypropylmethacrylate) (PGMA-N3), and a fluorescence-based imaging component Rhodamine B (RhB) and galactose are used as targeting ligands. The drug delivery system provided by the present disclosure is safe, is capable of taking a synergistic effect of gene/drug therapy, and is expected to play a great role in clinical application.
展开▼