INDUCTION OF NEURAL PROGENITOR CELLS, OLIGODENDROCYTE PROGENITOR CELLS, AND OLIGODENDROCYTES BY STEM CELL DIFFERENTIATION USING LANDMARK TRANSCRIPTION FACTORS

摘要

A novel method of inducing neural progenitor cells, oligodendrocyte progenitor cells, oligodendrocytes from human iPSCs at an unprecedented efficiency and functionality. The core of the invention is the use of experimentally discovered transcription factors at multiple critical differentiation decision points along a pluripotent to ectoderm, neural ectoderm to NPCs to OPCs to oligodendrocytes pathway in a previously unknown manner.