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ANTI-AGING TRANSGENIC CAENORHABDITIS ELEGANS

机译：抗衰老转基因蜡虫

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摘要

The present invention relates to: a transgenic Caenorhabditis elegans in which a glutamine tRNA 5′ terminus-derived fragment (Gln 5′-tsRNA) is overexpressed; a preparation method therefor; and a method for screening for aging-associated factors by using the transgenic Caenorhabditis elegans. A transgenic Caenorhabditis elegans model provided in the present invention is an animal model in which Gln 5′-tsRNA is overexpressed such that aging is inhibited. When the model of the present invention is used, anti-aging mechanisms can be easily investigated, thereby significantly contributing to various research fields such as that of developing new anti-aging drugs and screening for age-inducing materials.

机译：本发明涉及：转基因的线虫秀丽隐杆线虫，其中谷氨酰胺tRNA 5＆＃x2032;末端衍生片段（Gln 5＆＃x2032; -tsRNA）过表达;其制备方法;以及使用转基因秀丽隐杆线虫筛选衰老相关因子的方法。本发明提供的转基因秀丽隐杆线虫模型是其中Gln 5＆＃x2032; -tsRNA过表达从而抑制衰老的动物模型。当使用本发明的模型时，可以容易地研究抗衰老机制，从而显着地促进了各种研究领域，例如开发新的抗衰老药物和筛选引起衰老的物质。

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公开/公告号US2019200589A1

专利类型
公开/公告日2019-07-04

原文格式PDF
申请/专利权人 POSTECH ACADEMY-INDUSTRY FOUNDATION;INSTITUTE FOR BASIC SCIENCE;DAEGU GYEONGBUK INSTITUTE OF SCIENCE;
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申请/专利号US201716095414
发明设计人 HONG GIL NAM;GYOO YEOL JUNG;SEUNG JAE LEE;WOO SEON HWANG;GI WON SHIN;MI HWA SEO;
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申请日2017-04-21
分类号A01K67/033;C12N15/89;A61K49;C12N15/113;
国家 US
入库时间 2022-08-21 12:07:13

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