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System and Method For Evaluation of Subjects Using Magnetic Resonance Imaging and Oxygen-17
System and Method For Evaluation of Subjects Using Magnetic Resonance Imaging and Oxygen-17
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机译:使用磁共振成像和氧气17评价受试者的系统和方法
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摘要
A system and method for evaluating subjects using MRI and a contrast agent that overcomes the low sensitivity nature of previous detection methods is provided by using a 3D golden-angle-based radial sampling approach. In one configuration, direct detection of metabolic H217O generated from mitochondrial respiration may be imaged. Radial encoding allows for the use of ultra-short echo-time to compensate for signal loss due to the short T2 relaxation time of 17O and other contrast agents. In addition, the golden-ratio-based sampling scheme has the flexibility of enabling various undersampling schemes and retrospective selection of temporal resolution for dynamic imaging. A 3D radial sampling scheme may also give rise to additional SNR gain by further shortening the echo-time.
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