AMINO MERCAPTAN COMPOUND AND PREPARATION METHOD THEREFOR AND USE THEREOF IN PROTECTION AGAINST RADIATION

摘要

The present invention discloses an amino mercaptan compound, preparation method thereof and use thereof in radiation protection. The compound has the structure of formula I, wherein A₁ is selected from: —C(O)NR⁸—, —S(O)₂—NR⁸—, —S(O)NR⁸—, and —R⁷—NR⁸—; A₂ is selected from: carbonyl, sulfonyl, sulfinyl, substituted or unsubstituted C_1-6 alkyl; R¹, R², R⁵, and R⁶ may be the same or different and are selected from: hydrogen, substituted or unsubstituted C₁-C₅ alkyl or heteroalkyl; n is an integer from 0 to 20,000; R³ and R⁴ are independently selected from: hydrogen, X, substituted or unsubstituted C_1-6 alkyl; X is selected from: F, Cl, Br and I; R⁷ is selected from: substituted or unsubstituted C₁-C₆ alkyl; and R⁸ is selected from: hydrogen, substituted or unsubstituted C₁-C₆ alkyl. The compound has the effects of reducing the biological damage caused by ionizing radiation, extending the survival period and survival rate of the radiated animals, and significantly alleviating the side effects of radiotherapy, and has a low toxicity. The present invention opens up a new way for protection and treatment of ionizing radiation damage.;