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Selective Inhibitors of the Polo-Like Kinase 1 Polo-Box Domain
Selective Inhibitors of the Polo-Like Kinase 1 Polo-Box Domain
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机译:Polo类激酶1 Polo-Box域的选择性抑制剂
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摘要
Inhibitors that are specific for the PBD domain of the PLK1 protein are described. The inhibitors include fragment ligated inhibitors that include one or more amino acids of a starting peptide upon which the inhibitors are based and also include non-peptidic inhibitors. The inhibitors include a benzoic acid-based derivative that mimics the structure activity relationship of amino acid residues of known peptide inhibitors. The inhibitors exhibit high selectivity for the PLK1 isotype.
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