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ORIENTED IMPLANTS CONTAINING POLY(BUTYLENE SUCCINATE) AND COPOLYMER, AND METHODS OF USE THEREOF
ORIENTED IMPLANTS CONTAINING POLY(BUTYLENE SUCCINATE) AND COPOLYMER, AND METHODS OF USE THEREOF
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机译:包含聚丁二酸丁二醇酯和共聚物的定向植入物及其使用方法
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摘要
Resorbable implants comprising poly(butylene succinate) and copolymers thereof have been developed. The implants implants are preferably sterilized, and contain less than 20 endotoxin units per device as determined by the limulus amebocyte lysate (LAL) assay, and are particularly suitable for use in procedures where prolonged strength retention is necessary, and can include one or more bioactive agents. The implants may be made from fibers and meshes of poly(butylene succinate) and copolymers thereof, or by 3d printing, and the fibers may be oriented. Coverings and receptacles made from forms of poly(butylene succinate) and copolymers thereof have also been developed for use with cardiac rhythm management devices and other implantable devices. These coverings and receptacles may be used to hold, or partially/fully cover, devices such as pacemakers and neurostimulators. The coverings and receptacles are made from meshes, webs, lattices, non-wovens, films, fibers, and foams, and contain antibiotics such as rifampin and minocycline.
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