A fatigue state determination device and a fatigue state determination method determine a fatigue state of a subject. The fatigue state determination device includes a brain-function activation information provision unit and a fatigue state determination unit. The brain-function activation information provision unit provides brain-function activation information in order to activate a human brain function of a subject. The fatigue state determination unit determines a fatigue state of the subject based on facial-surface change information indicative of a time-series change of facial surface data on the subject while the brain-function activation information is being provided.
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