首页> 外国专利> COMPOSITIONS FOR PREVENTING OR TREATING SEPSIS OR SEPTIC SHOCK COMPRISING ADK PROTEIN AS ACTIVE INGREDIENT

COMPOSITIONS FOR PREVENTING OR TREATING SEPSIS OR SEPTIC SHOCK COMPRISING ADK PROTEIN AS ACTIVE INGREDIENT

机译:预防或治疗脓毒症或脓毒症的成分,含有ADK蛋白作为有效成分

摘要

The present invention relates to a composition for preventing or treating sepsis or septic shock including a Mycobacterium tuberculosis-derived adenosine kinase (ADK) protein as an active ingredient. The Mycobacterium tuberculosis-derived ADK protein according to one exemplary embodiment of the present invention has an effect of inhibit binding between the LPS and cells by binding to LPS, and also has an excellent therapeutic effect against sepsis by enhancing viability in a sepsis animal model and suppressing inflammatory response in the lung and cell death in the spleen.
机译:本发明涉及一种用于预防或治疗败血症或败血性休克的组合物,其包含源自结核分枝杆菌的腺苷激酶(ADK)蛋白作为有效成分。根据本发明的一个示例性实施方案的源自结核分枝杆菌的ADK蛋白具有通过与LPS结合而抑制LPS与细胞之间的结合的作用,并且还通过增强对脓毒症的治疗效果优异。在败血症动物模型中具有生存力,并能抑制肺部的炎症反应和脾脏中的细胞死亡。

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