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MATERIALS AND METHODS FOR EFFECTIVE IN VIVO DELIVERY OF DNA NANOSTRUCTURES TO ATHEROSCLEROTIC PLAQUES
MATERIALS AND METHODS FOR EFFECTIVE IN VIVO DELIVERY OF DNA NANOSTRUCTURES TO ATHEROSCLEROTIC PLAQUES
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机译:DNA纳米结构体内有效递送至动脉粥样硬化斑块的材料和方法
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摘要
Provided are DNA-coated nanoparticles (DNA-NPS), superparamagnetic nanoparticles (DNA-SPNs), and superparamagnetic iron oxide nanoparticles (DNA-SPIONs) as efficient imaging agents for targeting and imaging atherosclerotic lesions and treating atherosclerotic disease. The DNA-NS, DNA-SPNs, and DNA-SPIONs can enter macrophage cells via the Class A scavenger receptor (SR-A)-mediated pathways and can be used to specifically target atheroscleortic plaques.
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