Human Serum Albumin Binding Compounds and Fusion Proteins Thereof

摘要

The present invention relates to a polypeptide binding to human serum albumin and comprising or consisting of an amino acid sequence selected from the group consisting of: (a) GVTLFVALYDY(X¹)(X²)(X³)(X⁴)(X⁵)(X⁶)D(X⁷)SFHKGEKFQIL(X⁸)(X⁹)(X¹⁰)(X¹¹)(X¹²)G(X¹³)(X¹⁴)W(X¹⁵)(X¹⁶)RSLTTG(X¹⁷)(X¹⁸)G(X¹⁹)IPSNYVAPVDSIQ (SEQ ID NO: 1), wherein (X¹) is A, V, I, L, M, G, P, S, T, N, Q, C, R, H, K, D or E; (X²) is R, H, K, A, V, I, L, M, G, P, S, T, N, Q or C; (X³) is R, H, K, S, T, N, Q, C, F, Y, W, A, V, I, L, M, G or P; (X⁴) is S, T, N, Q, C, A, V, I, L, M, G, P, R, H, K, F, Y, W, D or E; (X⁵) is S, T, N, Q, C, D, E, F, Y, W, A, V, I, L, M, G, P, R, H or K; (X⁶) is F, Y, W, A, V, I, L, M, G, P, R, H, K, S, T, N, Q or C; (X⁷) is A, V, I, L, M, G, P, R, H or K; (X⁸) is S, T, N, Q, C, D or E; (X⁹) is S, T, N, Q, C, D, E, A, V, I, L, M, G, P, F, Y or W; (X¹⁰) is A, V, I, L, M, G or P; (X¹¹) is F, Y, W, R, H or K; (X¹²) is S, T, N, Q, C, F, Y or W; (X¹³) is F, Y, W, R, H, K, S, T, N, Q, C, D, E, A, V, I, L, M, G or P; (X¹⁴) is F, Y, W, A, V, I, L, M, G or P; (X¹⁵) is D, E, A, V, I, L, M, G or P; (X¹⁶) is A, V, I, L, M, G or P; (X¹⁷) is D, E, A, V, I, L, M, G, P, R, H or K; (X¹⁸) is S, T, N, Q, C, A, V, I, L, M, G or P; (X¹⁹) is F, Y, W, S, T, N, Q or C; and (b) an amino acid sequence which is at least 90% identical to the amino acid sequence of (a), wherein the identity determination excludes amino