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New Combination of active agents for the treatment of Progressive Fibrosing Interstitial Lung Diseases (PF-ILD)
New Combination of active agents for the treatment of Progressive Fibrosing Interstitial Lung Diseases (PF-ILD)
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机译:用于治疗进行性纤维化间质性肺病(PF-ILD)的新型活性剂组合
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摘要
The application refers to a novel combination treatment/combination medicament for PF-ILD treatment, comprising as a first combination partner a therapeutically effective amount of Nintedanib or a pharmaceutically acceptable salt thereof and as a second combination partner a therapeutically effective amount of a PDE4B-inhibitor of formula I; ;wherein Ring A is a 6-membered aromatic ring which may optionally comprise one or two nitrogen atoms andwherein R is Cl and wherein R may be located either in the para-, meta- or ortho-position of Ring A,wherein S* is a sulphur atom that represents a chiral centeror a pharmaceutically acceptable salt thereof.;Hereby the second combination partner is preferably a therapeutically effective amount of the PDE4B-inhibitor of formula III; ;or a pharmaceutically acceptable salt thereof.
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