首页> 外国专利> CD147 AS RECEPTOR FOR PILUS-MEDIATED ADHESION OF MENINGOCOCCI TO VASCULAR ENDOTHELIA

CD147 AS RECEPTOR FOR PILUS-MEDIATED ADHESION OF MENINGOCOCCI TO VASCULAR ENDOTHELIA

机译：CD147作为脑膜炎球菌对血管内皮的黏附的受体

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摘要

The present invention concerns the use of an inhibitor of an interaction between type IV pilus-associated protein and CD147 for preventing or treating meningoccal bacteraemia and/or infection. The present invention also relates to the combined use of such inhibitor and of an anti-bacterial compound, such as one used to prevent or treat a meningococcal infection. The invention also relates to a method for the prevention and/or treatment of meningococcal bacteraemia and/or infection, and to a method for screening inhibitors of the interaction between type IV pilus-associated protein and CD147.

机译：本发明涉及IV型菌毛相关蛋白和CD147之间的相互作用的抑制剂在预防或治疗脑膜炎性菌血症和/或感染中的用途。本发明还涉及这种抑制剂和抗菌化合物例如用于预防或治疗脑膜炎球菌感染的化合物的组合用途。本发明还涉及预防和/或治疗脑膜炎球菌菌血症和/或感染的方法，以及筛选IV型菌毛相关蛋白和CD147之间相互作用的抑制剂的方法。

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公开/公告号US2018340017A1

专利类型
公开/公告日2018-11-29

原文格式PDF
申请/专利权人 INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE;UNIVERSITE PARIS DESCARTES;
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申请/专利号US201815990170
发明设计人 XAVIER NASSIF;SANDRINE BOURDOULOUS;OLIVIER JOIN-LAMBERT;
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申请日2018-05-25
分类号C07K14/705;C12N15/113;A61K39/395;A61K39/40;
国家 US
入库时间 2022-08-21 12:04:52

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