首页> 外国专利> MASS ANALYSIS DATA ANALYZING APPARATUS AND MASS ANALYSIS DATA ANALYZING PROGRAM

MASS ANALYSIS DATA ANALYZING APPARATUS AND MASS ANALYSIS DATA ANALYZING PROGRAM

机译:质量分析数据分析装置和质量分析数据分析程序

摘要

Problem to be Solved;To select a marker peak which characterizes a difference between groups, even when the number of samples belonging to each group is small.;Solution;A peak matrix is created based on the peaks detected from mass spectra of a plurality of samples belonging to a plurality of groups (S1-S3). Each row of the peak matrix represents a peak-intensity distribution for a large number of samples at one mass-to-charge-ratio value. If there is no difference between the groups at a certain mass-to-charge-ratio value, the peak-intensity distribution at that mass-to-charge-ratio value should be a lognormal distribution (or normal distribution). Accordingly, a hypothesis test for the conformity of the peak-intensity distribution to the lognormal distribution is performed for each mass-to-charge-ratio value (S5). A mass-to-charge-ratio value at which a significant difference has been found is selected as a candidate of the marker peak (S6).
机译:要解决的问题;即使在属于每个组的样本数量很小的情况下,也要选择能够表征组之间差异的标记峰。解决方案;基于从多个质谱图的质谱检测到的峰创建峰矩阵属于多个组(S 1 -S 3 )的样本。峰矩阵的每一行代表一个质​​荷比值下大量样品的峰强度分布。如果在某个质荷比值下组之间没有差异,则在该质荷比值下的峰强度分布应为对数正态分布(或正态分布)。因此,对于每个质荷比值(S 5 ),进行峰强度分布与对数正态分布的符合性的假设检验。选择发现明显差异的质荷比值作为标记峰(S 6 )的候选值。

著录项

  • 公开/公告号US2018340827A1

    专利类型

  • 公开/公告日2018-11-29

    原文格式PDF

  • 申请/专利权人 SHIMADZU CORPORATION;

    申请/专利号US201815986306

  • 发明设计人 YOSIHIRO YAMADA;HIROTO TAMURA;TERUYO KATO;

    申请日2018-05-22

  • 分类号G01J3/28;G06F17/18;H01J49/26;H01J49/02;C12Q1/689;C12Q1/6895;

  • 国家 US

  • 入库时间 2022-08-21 12:04:44

相似文献

  • 专利
  • 外文文献
  • 中文文献
获取专利

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号