Composition of protein and polisacÁrido NEUMOCÓCICA multivalent Conjugate

摘要

Multivalent pneumococcal conjugate compositions comprising Carrier mixed with 20 different conjugated pneumococcal capsular polysaccharide and ProteinWhere each of the capsular polysaccharide conjugate includes a different Serotype of Streptococcus pneumoniae conjugated either with Tetanus toxoid or crm₁₉₇,The serotypes of Streptococcus pneumoniae are selected from 1, 3, 4, 5, 6a, 6B, 9V, 7f, 8, 10a, 11A, 12F, 14, 15B, 18C, 19F, 23F, 19a, 22F, and 33F,Where are two of the capsular polysaccharide conjugated to Tetanus Toxoid and the remaining capsular polysaccharide is conjugated with crm₁₉₇,And where the two capsular polysaccharide conjugated to Tetanus toxoid are selected from the group consisting of serotypes 1, 3 and 5.Methods for producing the compositions multivalent pneumococcal conjugate mixed with Carrier and Methods for their use for prophylaxis against infection or disease due to Streptococcus pneumoniaIAE in a subject.