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PROCESS FOR PRODUCING PARTICLES OF A PARTICULATE SALT OF ECPHINOMA ACID, PARTICLES OF A PARTICULATE SALT OF ECPHINOMA ACID, AND PHARMACEUTICAL FORMULATION
PROCESS FOR PRODUCING PARTICLES OF A PARTICULATE SALT OF ECPHINOMA ACID, PARTICLES OF A PARTICULATE SALT OF ECPHINOMA ACID, AND PHARMACEUTICAL FORMULATION
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机译:麦芽孢酸颗粒盐的颗粒的制备,麦芽孢酸颗粒盐的颗粒的制备和药物配方
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摘要
process for the production of particles of a cefquinome acid addition salt, particles of a cefquinome acid addition salt, and pharmaceutical formulation describes a process for the production of particles of a cefquinome acid addition salt, preferably cefquinome sulfate particles, by precipitation of the cefquinome acid addition salt, preferably sulfate, of a betaine cefquinome solution, wherein acid, preferably sulfuric acid, is added to the betaine solution. According to the invention the acid, preferably sulfuric acid, is added rapidly in a single injection in a molar excess of 40 ° / o to less than 100 ° / o. As a result, particles are formed comprising agglomerates of primary microscale crystalline particles. This enables the delivery of cefquinome acid addition salt particles, preferably cefquinome sulfate, in particle sizes proportional to the micronized material, but with improved stability.
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