chiral heterogeneous catalyst by asymmetric nitroaldol reaction.

摘要

The present invention relates to the preparation of highly efficient chiral heterogeneous catalyst for asymmetric nitroaldol reaction, wherein Henry reactions of various aldehydes such as aromatic, aliphatic, alpha,beta-unsaturated aldehydes, alicyclic aldehydes and nitroalkenes were carried out to produce optically active beta-nitroalcohols in high yield, with moderate to excellent enantioselectivity (ee up to 99%) in presence of a base and an optically active chiral heterogeneous catalyst.