cross-linking reagents, macromolecules, therapeutic conjugates and synthetic methods

摘要

patent summary: "cross-linking reagents, macromolecules, therapeutic conjugates and synthetic methods thereof". The present invention relates to novel chemical entities based on sugar alcohols. These new chemical entities are biocompatible and biodegradable. The molecules can be made in a simple and pure form. The molecular weights of these molecules range from low (1000 da) to high (1000-120,000 da). sugar alcohol-based molecules may have functional groups throughout the molecule for cross-linking compounds, such as the preparation of antibody-drug conjugates, or to facilitate the application of therapeutic proteins, peptides, sirna and drugs. chemotherapeutic agents. New conjugate entities prepared via sugar alcohol molecules are also provided. Synthesis methods of sugar alcohol-based molecules and conjugates are also within the scope of the invention.