method for treating cancer in a subject, composition and methods of increasing the number of nk cells and increasing the number of one or more pd-11 positive cells

摘要

The uses of fibroblast growth factor receptor 2 (fgfr2) inhibitors in the treatment of cancer are provided herein in some cases in combination with immunostimulating agents such as pd-1 or pd-11 inhibitors. in some embodiments, fgfr2 inhibitors may comprise fgfr2 antibodies or fgfr2 extracellular domain (ecd) polypeptides or fgfr2 ecd fusion molecules comprising an fgfr2 ecd and a fusion partner. In some embodiments, pd-1 / pdl-1 inhibitors may comprise anti-pd-1 antibodies such as antibodies that bind to pd-1 or pd-11 and inhibit interactions between such proteins as well as fusion proteins or polypeptides. from pd-1.