reduction of tumor burden by administration of ccr1 antagonists in combination with pd-1 inhibitors or pd-11 inhibitors

摘要

The present invention provides methods for reducing tumor burden, tumor growth, tumor progression and / or metastasis in an individual suffering from solid tumor cancer such as triple negative breast cancer. The methods include administering to a subject in need thereof a therapeutically effective amount of a pd-11 inhibitor or a pd-1 inhibitor in combination with a small molecule chemokine receptor antagonist that blocks ccr1.